Manufacturing Companies for 0 – Oxytetracycline Hydrochloride - Compound Levamisole bolus 900mg – Fangtong

Levamisole HCl 450mg + Oxyclozanide 450mg bolus

COMPOSITION

Each bolus contains Levamisole HCl 450mg and Oxyclozanide 450mg.

DESCRIPTION

LEVAOXYNIDE 900 is a pink colored tablet for oral dosing.

INDICATIONS

LEVAOXYNIDE 900 is a broad spectrum anthelmintic for use in the treatment and control of gastro-intestinal and pulmonary nematode infections and chronic fascioliasis in sheep and goats and cestodes in sheep.

- Lungworms: Dictyocaulus spp.

- Gastro-intestinal worms: Haemonchus spp., Ostertagia spp., Nematodirus spp., Trichostron-gylus spp.,

Cooperia spp., Oesophagostomum spp., Bunostomum spp.

LEVAOXYNIDE 900 also removes most mature Fasciola spp. (flukes) present in the bile duct of the liver.

PHARMACODYNAMICS

Levamisole is the laevo-enantiomer of tetramisole and is an anthelmintic imidazothiazole. It is effective upon oral administration against various species of nematodes. Its anthelmintic action is characterised by paralysis of the worm through a neuromuscular inhibition of the depolarising type, leading to passive elimination of the worm.

Oxyclozanide is an anthelmintic of the salicylanilide group. It is effective against Fasciola species, acting as an uncoupler of oxidative phosphorylation. It may act at more than one site to decrease levels of ATP leading to metabolic malfunction and death of the parasite.

PHARMACOKINETICS

Levamisole is very rapidly absorbed and peak plasma concentrations are attained on average 1 to3 hours after oral dosing. Levamisole is rapidly distributed to all tissues, where levels are several times higher than the corresponding plasma levels. Elimination from plasma and tissues is also very rapid, the main elimination routes being the urine and the bile.

Oxyclozanide is slowly absorbed after oral administration with peak plasma levels 24 hours after dosing. Excretion is predominantly faecal, biliary excretion being the most important route of elimination.

DOSAGE AND ADMINISTRATION

1 bolus per 30-40kg body weight.

SIDE EFFECTS

May cause occasionally diarrhea, inappetence, frothing, salivation and respiratory distress.

WARNINGS AND PRECAUTIONS

- For animal treatment only.

- Keep out of reach of children.

WITHDRAWAL PERIOD

-3 days for milk.

-28 days for meat.

STORAGE

Store in a cool, dry and dark place below 30℃.

PRESENTATION

5 Boli×12 Strips/Box.

VALIDITY

4 years.

MANUFACTURED BY

Chongqing Fangtong Animal Pharmaceutical Co., Ltd

Banqiao Industrial Park, Rongchang, Chongqing, China