Ivermectin 1% + Closantel 10% Injection

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APPEARANCE It is an amber to brownish yellow clear liquid. COMPOSITION Each ml contains: Ivermectin 10mg, Closantel: 100mg. INDICATION For the treatment of mixed trematode (fluke) and nematode or arthropod infestations due to gastrointestinal roundworms, lungworms, eyeworms, warbles, mites and lice of cattle. Gastrointestinal roundworms Ostertagia ostertagi (including inhibited larval stages), Ostertagia lyrata (adult), Haemonchus placei (adult and immature), Trichostrongylus axei (adult and ...


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APPEARANCE

It is an amber to brownish yellow clear liquid.

COMPOSITION

Each ml contains: Ivermectin 10mg, Closantel: 100mg.

INDICATION

For the treatment of mixed trematode (fluke) and nematode or arthropod infestations due to gastrointestinal roundworms, lungworms, eyeworms, warbles, mites and lice of cattle.

Gastrointestinal roundworms

Ostertagia ostertagi (including inhibited larval stages), Ostertagia lyrata (adult), Haemonchus placei (adult and immature), Trichostrongylus axei (adult and immature), Trichostrongylus colubriformis (adult and immature), Cooperia oncophora (adult and immature), Cooperia punctata (adult and immature), Cooperia pectinata (adult and immature), Oesophagostomum radiatum (adult and immature), Nematodirus helvetianus (adult), Nematodirus spathiger (adult), Strongyloides papillosus (adult), Bunostomum phlebotomum (adult and immature), Toxocara vitulorum (adult), Trichuris spp.

Lungworms

Dictyocaulus viviparus (adult and 4th stage larvae).

Liver Fluke (trematodes)

Fasciola gigantica, Fasciola hepatica.

Treatment of fluke at 12 weeks (mature) >99% efficacy.

Treatment of fluke at 9 weeks (late immature) >90% efficacy.

Eyeworms (adult)

Thelazia spp.

Cattle grubs (parasitic stages)

Hypoderma bovis, Hypoderma lineatum.

Lice

Linognathus vituli, Haematopinus eurysternus, Solenopotes capillatus.

Mange Mites

Psoroptes ovis (syn P communis var bovis), Sarcoptes scabiei var bovis.

CONTRAINDICATIONS

IVERTEL is not for intravenous or intramuscular use.

Avermectins may not be well tolerated in all non-target species (cases of intolerance with fatal outcome

are reported in dogs  especially Collies, Bobtails, Old English Sheepdogs and related breeds or crosses,

and also in turtles/tortoises).

Do not use in cases of known hypersensitivity to the active ingredients.

Do not administer concomitantly with chlorinated compounds.  The effect of GABA agonists are increased by ivermectin.

SPECIAL PRECAUTIONS FOR USE

Doses of more than 10ml should be injected in two different sites in order to reduce the transitory discomfort or reactions at the injection site.

It is not advisable to administer the product when Hypoderma lineatum larvae are localised in the periaesophagic region, or when Hypoderma bovis larvae are situated in the spinal canal.  Seek professional veterinary advice to determine the best period of use.

DOSAGE AND ADMINISTRATION ROUTE

Subcutaneous Injection.

1 ml per 50 kg. body weight, equivalent to 200 mcg/kg Ivermectin and 2 mg/kg Closantel.

OVERDOSE

Single doses of 4.0 mg/kg ivermectin (20 times the recommended dosage) administered subcutaneously, result in ataxia and depression. No antidote has been identified. Symptomatic treatment may be beneficial.

Signs overdosage of Closantel can include loss of appetite, decreased vision, loose faeces and increased frequency of defaecation.  High doses may cause blindness, hyperventilation, hyperthermia, general weakness, inco-ordination, convulsions, tachycardia and in extreme cases death. Treatment of overdosage is symptomatic as no antidote has been identified.

WITHDRAWAL PERIOD

Meat: 35 days.

Not permitted for use in cattle producing milk for human consumption.

Do not use in non-lactating dairy cows including pregnant heifers which are intended to produce milk

for human consumption within 60 days of expected parturition.

Do not use any closantel-containing products during the 35 day withdrawal period.

VALIDITY

2 years.

PRESENTATION

In a 50ml or 100ml bottle.

STORAGE

Stored in a cool, dry and dark place.


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