Trypatong

Each 2.36g contains:

Diminazene aceturate ................................ 1.05g

Antipyrine ................................................ 1.31g

A yellow or orange, crystalline powder, odourless. It will become the orange-red in the light or hot situation.

The antiparasitic activity of the aromatic diamidines may be related to the interference with aerobic glycolysis as well as interference with synthesis of deoxyribonucleic acid (DNA) in the parasite. All these drugs give rise to hypoglycemia in the treated host. Babesia as well as many other forms of parasites like trypanosomes depend upon host glucose for aerobic glycolyses. Specifically, the mechanism of trypanocidal action of pentamidine, INN, is said to depend on the drug's inhibition of aerobic glycolysis and denaturing of nulceoproteins of the parasite.

Selective blocking of kinetoplast DNA replication appears to be the mode of acitivity of diminazene, INN. It is rapidely and irreversibly bound by the DNA-containing organelles of the trypanosome, first in the kinetoplast and subsequently in the nucleus. The ratio of binding is 1 molecule of diminazene for every 4 - 5 DNA nucleotides. Further studies strongly suggest that the drug-DNA complex inhibits kinetoplasts DNA synthesis. The exact relation of this to the death of the trypanosomes is not known, nor is the significance of nuclear DNA binding of the drug. Thus many questions are still unanswered relative to the activity of the diamidines; practically no studies of this nature have been conducted with babesial organisms.

In addition to tripanocidal activity diminazene also acts babesicidal and bactericidal (mainly Brucella and Streptococcus species).

As a trypanocide, diminazene is effective against T. vivax and T. congolense but less effective agains T. brucei, necessitating an increased dosage rate against this species.

The main fields of application are both mixed infections caused by tryanosome and piroplasma infections caused by resistant strains of malaria parasites. In case of infection with Trypanosoma congolense and Trypanosoma vivax, one administration will result in a complete cure. In case of infection with Babesia on the other hand, a normal dose produces a rapid clinical recovery, but does not completely eliminate the parasites from the blood. In this way, animals can develop a state of premunition.

By deep intramuscular injection. Split the amount by injecting at several locations when big volume.

Dissolve 1 sachet of 2.36g powder in 12.5 ml of sterile water for injection to obtain a ready to use solution of 7% (about 15ml). The recommended dosage for each animals is 3.5 mg of Diminazene per kg body weight (1ml/20kg). For infections with Trypanosoma brucei, the dosage should be doubled (2ml/20kg). If the causative organism is particularly strong, the dosage may be increased to 8 mg Diminazene per kg body weight (1ml/8.75kg), but without injecting more than 4g Diminazene per animal. Usually one injection is enough for the treatment. If the animal does not recover after one injection, consult a veterinarian for further treatment.

The drug is toxic, sometimes it could be seen restless, urinating frequently and muscle twitching.

Intramuscular injection has irritation, it may cause swelling. When large quantity of the solution is administered, it’s recommended to give the injection at several sites in order to avoid local pain.

Buffalos are sensitive, be cautious when continual application.

Milk production quantity of cow will reduce because of large dose.

Meat and offal: 21 days; Milk: 5 days.

2.36g / sachet × 10 sachets / box, or 2.36g / sachet × 100 sachets / box .

Store in a cool and dry place below 30℃, protect from light.

Used immediately after reconstitution.

5 years.