Key technological breakthrough of Fangtong long-acting oxytetracycline injection

Fangtong Oxytetracycline Injection uses PVP as a carrier to form a complex with oxytetracycline (see Fig. 1). This formulation addresses the common problems of conventional high-concentration oxytetracycline injections, such as dark coloration, susceptibility to oxidative discoloration, precipitation, difficulty in injection, and strong tissue irritation.

Figure 1: Core Technology 1: PVP Carrier Mediated Drug Delivery System

 Core Technology 2: Gold Complexation Ratio

By precisely controlling the chelation time and temperature, oxytetracycline and magnesium ions are combined in an optimal ratio, ensuring maximum stability of oxytetracycline in the injection. As a result, the product resists oxidative discoloration and precipitation.

Advantage 1: Non-irritant

The PVP carrier significantly improves the transport rate of oxytetracycline, reducing its precipitation and residue at the injection site and thereby minimizing local irritation. When administered at 0.05 ml/kg into the neck and hip of piglets for seven consecutive days, and examined after 28 days (withdrawal period), the injection sites showed intact skin without swelling or abscesses. Upon dissection, both superficial and deep muscles were intact, with no congestion or degeneration. The mean muscle irritation score was 0, indicating no irritation.

Figure 2: Irritation Test of Long acting Oxytetracycline Injection

Advantage 2: High Bioavailability

The PVP carrier transports oxytetracycline from the injection site into systemic circulation and releases it gradually at different sites, providing a long-acting sustained-release effect. Pharmacokinetic studies showed that the effective plasma concentration time was ≥72 hours, with relative bioavailability ≥90%.

Figure 3: Pharmacokinetic Study of Long Acting Oxytetracycline Injection

Advantage 3: The “Clear Bottle” Era of Oxytetracycline Injections

This long-acting oxytetracycline injection is highly stable and insensitive to light. It remains clear and free of precipitation in transparent glass or plastic bottles. There is no need for storage in brown bottles to avoid light exposure—the clarity and color are visible at all times.

Figure 4: Transparent bottled oxytetracycline injection

Advantage 4: The Only Oxytetracycline Product Suitable for Intravenous Infusion

When diluted with glucose injection, sodium chloride injection, or glucose-sodium chloride injection in varying ratios, the solution remained clear, free of precipitation, and stable in content within 1 hour (see Fig. 5).

Figure 5: Combination of Oxytetracycline and Different Injections for Intravenous Dripping

Advantage 5: Stability After Opening (≥28 Days)

Within 28 days of opening, the long-acting oxytetracycline injection showed no significant changes in color or content (see Fig. 6), provided that a sterile syringe was used and no external contamination was introduced.

Figure 6: Stability of oxytetracycline injection after opening

Applications of Long-Acting Oxytetracycline Injection

Oxytetracycline, a member of the tetracycline class, is a broad-spectrum antibiotic effective against Gram-positive and Gram-negative bacteria, rickettsiae, chlamydia, mycoplasma, spirochetes, actinomycetes, and certain protozoa. As one of the most widely used antibiotics in livestock and poultry, it is commonly applied in the treatment of respiratory, urogenital, and gastrointestinal infections caused by bacteria, mycoplasma, and chlamydia.

1. Respiratory diseases: For respiratory infections such as mycoplasmosis, swine pneumonia, pasteurellosis, infectious pleuropneumonia, atrophic rhinitis, Haemophilus parasuis infection, and secondary viral infections.

2. Piglet “three-shot health program: In pig farms with severe yellow and white scour, mycoplasmosis, and hemoparasites, oxytetracycline may be used for preventive “three-shot” health management, targeting neonatal diarrhea, enteritis, scours, bacterial enteric infections, typhoid, edema disease, mycoplasmosis, and eperythrozoonosis.

3. Postpartum sow inflammation: For postpartum diseases, stress-related complications, and respiratory disorders.

4.Hemoparasitic diseases: For infections caused by hemoplasma, toxoplasma, leptospira, mycoplasma, and other blood parasites, which typically present with high fever, dark urine, jaundice, red or pale mucous membranes, and yellowish ocular membranes.