Ivertong Super

Each ml contains: Ivermectin 5 mg，Closantel 125 mg.

It is an amber to brownish yellow clear liquid.

Ivermectin is an endectocide with activity against a wide range of internal andexternal parasites. Ivermectin is a macrocyclic lactone and acts by inhibiting nerveimpulses. It binds selectively and with high affinity to glutamate-gated chloride ionchannels which occur in invertebrate nerve and muscle cells. This leads to an increase in the permeability of the cell membrane to chloride ions with hyperpolarization of the nerve or muscle cell, resulting in paralysis and death ofthe relevant parasites. Compounds of this class may also interact with otherligand-gated chloride channels, such as those gated by the neurotransmittergamma-aminobutyric acid (GABA). The margin of safety for compounds of thisclass is attributable to the fact that mammals do not have glutamate-gated chloridechannels. The macrocyclic lactones have a low affinity for other mammalianligand-gated chloride channels and they do not readily cross the blood-brainbarrier.

Resistance to macrocyclic lactones has been reported in Teladorsagia andTrichostrongylus in sheep in a number of countries. Therefore the use of this medicinal product should be based on local (regional, farm) epidemiological information about susceptibility of parasites, local history of treatments andrecommendations on how to use the medicinal product under sustainableconditions to limit further selection for anthelmintic resistance.

P-glycoproteins (Pgps) have been frequently implicated in ivermectin resistanceand are a major cause of multi-drug resistance in protozoa and helminths.

Closantel is a member of the salicylanilide class of anthelmintics. Salicylanilidesare hydrogen (proton) ionophores (referred to as oxidative phosphorylaseuncouplers.)

The chemical structure of salicylanilides illustrate the possession of a detachableproton. This type of molecule is lipophilic and is known to shuttle protons acrossmembranes, in particular the inner mitochondrial membrane.

Closantel acts byuncoupling oxidative phosphorylation.Closantel is a parasiticide with flukicide activity and efficacy against certain otherhelminths and arthropods. Treatment with the veterinary medicinal product whenfluke are five weeks and greater has been shown to reduce subsequentreproductive capacity and egg shedding.

Ivertong Super is indicated for the treatment and control of mixed parasitic infections in cattle and sheep, including trematodes (liver flukes), gastrointestinal nematodes, lungworms, and arthropods (e.g., nasal bots, mange mites, lice). It is effective against adult and immature stages (e.g., L4 larvae, 8-week immature flukes) and demonstrates efficacy against benzimidazole-resistant strains of key parasites.

Cattle

Trematodes (Liver Flukes)

Fasciola hepatica (adult and 7-week immature), Fasciola gigantica (adult and 8-week immature)

Gastrointestinal Nematodes

Haemonchus placei (adult and immature), Ostertagia ostertagi (including inhibited L4),

Ostertagia lyrata, Trichostrongylus axei (adult), Trichostrongylus colubriformis (L4), Cooperia spp. (adult and L4), Oesophagostomum radiatum (adult and immature), Nematodirus spathiger (adult) and Bunostomum phlebotomum (adult and immature)

Lungworms

Dictyocaulus viviparus (adult and L4)

Arthropods

Warbles (Hypoderma): Hypoderma bovis (dermal stages), Hypoderma lineatum (dermal stages)

Mange Mites:Sarcoptes scabiei var. bovis, Psoroptes bovis

Lice:Linognathus vituli, Haematopinus eurystermus

Sheep

Trematodes (Liver Flukes)

Fasciola hepatica (adult), Fasciola gigantica (adult and 8-week immature)

Gastrointestinal Nematodes

Haemonchus contortus (adult, immature, and inhibited L4), Teladorsagia circumcincta (including inhibited L4), Trichostrongylus axei (adult), Trichostrongylus colubriformis (adult and L4), Cooperia curticei (adult and L4), Oesophagostomum columbianum (adult and L4), Chabertia ovina (adult and L4), Nematodirus filicollis (adult and L4), Trichuris ovis (adult), Gaigeria pachyscelis (adult and immature)

Lungworms

Dictyocaulus filaria (adult and L4), Protostrongylus rufescens (adult)

Arthropods

Nasal Bots: Oestrus ovis (1st, 2nd, 3rd instar)

Mange Mites: Psoroptes ovis (requires second ivermectin dose at 7 days)

Lice: Linognathus spp. (if applicable)

By subcutaneous injection only. 

Cattle and Sheep : 1 ml/25 kg body weight.

If treatment is to be repeated, a minimum interval of 35 days, must be observed in order to avoid accumulation of residues.

To ensure administration of a correct dose, bodyweight should be determined as accurately as possible; Choose proper dosing device and check the accuracy.

The timing for treatment should be based on epidemiological factors and should becustomised for each individual farm. Professional veterinary advice should besought on appropriate dosing programmes and stock management to achieve adequate parasite control and reduce the likelihood of resistance developing.

Transitory swelling has rarely been observed at the injection site and occasionally this swelling is accompanied by pain and discomfort. This swelling resolves completely within 14 days following treatment.

Do not use in administered to animals at any stage of pregnancy or lactation provided that the milk is not intended for human consumption.

Do not use by the intravenous or intramuscular route.

Do not use in animals known to be hypersensitive to the active substance.

Avermectins may not be well tolerated in all non-target species (cases of intolerance with fatal outcome are reported in dogs – especially Collies, Bobtails, Old English Sheepdogs and related breeds or crosses, and also in turtles/tortoises).

Meat and offal: 35 days.

Milk: Do not use in animals producing milk for human consumption.

Do not contaminate dams, rivers, streams or other waterways with the product or used container.

Available in 100 ml bottle.

Store in a cool and dry place not above 30℃, protect from light.

Use within 28 days after first opening.

Keep the container tightly closed after each opening.

3 years