Albentong sus 2.5%

Each ml contains Albendazole 25mg, solvent q.s.to 1 ml.

It is a yellow color suspension.

Pharmacodynamic properties

Albendazole acts on parasites by interfering with their energy generating metabolism. It inhibits fumaratereductase, which in turn prevents the generation of mitochondrial energy in the form of adenosine triphosphate (ATP). There is other evidence that the mode of action is the prevention of microtubule polymerisation. Differential binding affinities between nematode and mammalian tubulin may explain the selective toxicity of benzimidazoles.

Pharmacokinetic particulars

After oral administration of albendazole, up to 45% of the administered dose is absorbed into the bloodstream.Absorbed albendazole is very quickly metabolized in the liver to its sulfoxide derivative, which has also anthelmintic efficacy. The high plasma levels of albendazole sulfoxide make it effective against adult worms and immature stages in various host tissues and organs outside the gastrointestinal tract.In ruminants 60-70% of the administered dose is excreted through urine in the form of various metabolites, the major one being the sulfoxide. In sheep about 14% of the administered dose is excreted through the bile, partly in the form of various active metabolites, which enables reaching effective anthelmintic concentrations in the bile ducts.

Infestation with helminths susceptible to albendazole in sheep and cattle.

ALBENTONG SUS 2.5 is a broad spectrum anthelmintic effective in the removal and control of the following internal parasites: Adult Liver Flukes, Heads and Segments of Tapeworms (Moniezia); Adult and 4th Stage Larvae of intestinal Worm (Cooperia spp.), Hook Worm (Bunostomum spp.), Bankrupt Worm (Trichostrongylus spp.), Nodular Worm (Oesophagostomum) Adult and 4th Stage inhibited Larvae of Ostertagia, Barberpole Worm (Trichostongylus); Adult and 4th Stage Larvae of Lung Worms (Dictyocaulus).

Gastro intestinal worms, lungworms, tape worms:

Sheep&Goats: 1 ml/5 kg body weight.

Cattle: 3 ml/10 kg body weight.

Liver fluke or adult liver fluke:

Sheep&Goats: 2-3 ml/10 kg body weight for large liver fluke and 1 ml/2.5 kg body weight for small liver fluke.

Cattle: 1 ml/2.5 kg body weight for Fasciola hepatica; 3 ml/5 kg body weight for Fasciola gigantica, fasciala magna, paramphistomum.

Route of Administration: Oral.

Albendazole is tolerated without significant adverse effects when administered at recommended dose. Salivation, diarrhea, and rarely foaming of the muzzle may be observed in sheep, but will disappear within few hours.

1-Do not overdose.

2-Do not treat animals during first month of pregnancy.

Meat: 15 days before slaughter.

Milk: 5 days after the last treatment.

Store in a cool and dry place below 30℃, protect from light.

3 years.