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Ukunqoba icindezela amasosha omzimba ukuba alwe wegazi sezinkomo

Ukunqoba icindezela amasosha omzimba ukuba alwe wegazi sezinkomo

Ukunqoba icindezela amasosha omzimba ukuba alwe wegazi sezinkomo 配 图

I anti-sezinkomo PD-1 rat omzimba (ngakwesokunxele) utholakale engazinzile emzimbeni inkomazi kanye yayingakuthinti namagciwane. Ngakho, iqembu labacwaningi akha omzimba chimeric rat-sezinkomo (kwesokudla) okuyinto ngempumelelo wabonisa umphumela namagciwane.

wegazi Sezinkomo kuyinto letindzala, lymphosarcoma abulalayo izinkomazi okuyinto kwabangelwa ikakhulukazi ukutheleleka nge-retrovirus, sezinkomo wegazi igciwane (BLV). Ngo-2016, kwabikwa 3.125 amacala wegazi sezinkomo eJapane, okuyinto kwaba khona inani elikhulu izimo phakathi izifo ezithathelwanayo sezinkomo ebekwe Mthetho ku Domestic Animal Infectious Diseases Control. wegazi Sezinkomo is ngokuvamile kubonakala kwamanye amazwe ase-Asia, i-Ningizimu Melika naseNyakatho Melika.

Amaphesenti angu-35 izinkomo eJapane ziye kubikwa itheleleke nge BLV. Nakuba lesi sifo kudlangile ebangele ukulahlekelwa eside kwezomnotho ukuze yobisi yenkomo abalimi, okungazange kube khona Umuthi ophumelelayo wokugoma noma ukwelashwa etholakalayo ukulawula ukusabalala kanye ukuqhubeka kwesifo.

Ocwaningweni langaphambilini, ososayensi kusukela Hokkaido University, Tohoku University kanye Hokkaido Ucwaningo Inhlangano wathola ukuthi lymphocyte ngokuthi T-cellsare ezisebenza ukuyiveza ngumuntu nokuxhumana yokwamukela / ligand phakathi PD-1 kanye PD-L1 ngenkathi batheleleke nge BLV. I icindezela amasosha omzimba ihlobene eduze ukuqhubeka kwesifo. Ngaphezu kwalokho, zakha i omzimba elwisana PD-L1 okwakubekelwa bayithola iphumelela ekuvimbeni PD-1 / PD-L1 ukuxhumana kanye reinvigorating T-cell impendulo ku izinkomo ezithelelekile.

Esifundweni zamanje, nethimba labacwaningi bezazisa omzimba elwisana PD-1 ethathwe amagundane. Babe ihlolwe ukusebenza yayo ku inkomo ekuvimbeleni ukuqhubeka kwesifo. Nokho, akukho ekwenteni ncono T-cellactivity noma igciwane count watholakala, ngokusobala ngenxa nokuntengantenga omzimba emzimbeni inkomazi lapho Kuphethwe.

Ithimba ke izakhi anti-PD-1 rat omzimba ukwakha anti PD-1 "i-rat-sezinkomo" lwamasosha omzimba oluvame chimeric, okwakubekelwa futhi zaphathwa inkomazi elinegciwane. Babona lo asanda kwakhiwa amabhulokhi omzimba lo ngibopha phakathi PD-1 kanye PD-L1, reinvigorating unqulo wesi arab amasosha omzimba futhi ngaleyo ndlela ukunciphisa igciwane count inkomazi elinegciwane. Ngaphezu kwalokho, i-omzimba is hhayi axoshwe kalula emzimbeni inkomazi, okusenza sikwazi ukuhlala ngempumelelo ngaphakathi inkomo kuze kudlule isikhathi eside.

"I omzimba ezintsha ezingaze iholele ekuthuthukiseni biomedicines ukuthi ngempumelelo ukulapha izinkomo utheleleke nge sezinkomo wegazi igciwane. biomedicines okunjalo nazo zilindeleke ukuba sinciphise ukusetshenziswa kwemithi elwa namagciwane noma kwezidakamizwa nezinye izifo Ezingalapheki ezithathelwanayo, "kusho Hlobanisa UProfesa Satoru Konnai leqembu labacwaningi e-Hokkaido University. "Sihlela ukuqhuba isilwane ucwaningo kulo nyaka ukuze uqinisekise uma amasosha omzimba zethu ngempumelelo ekwelapheni nezinye izifo."

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isikhathi Iposi: Feb-27-2018
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