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Overcoming tiv thaiv kab mob hluav mus tua bovine leukemia

Overcoming tiv thaiv kab mob hluav mus tua bovine leukemia

Overcoming tiv thaiv kab mob hluav mus tua bovine leukemia 配 图

Cov anti-bovine PD-1 nas antibody (sab laug) twb pom tsis ruaj tsis khov nyob rau hauv lub nyuj lub cev thiab twb tsis muaj antiviral nyhuv. Yog li ntawd, cov pab neeg tshawb fawb tsim ib tug nas-bovine chimeric antibody (txoj cai) uas ntse pom ib tug antiviral nyhuv.

Bovine leukemia yog ib tug mauj, malignant lymphosarcoma nyob rau hauv nyuj uas yog tsuas yog tshwm sim los ntawm kev kis mob nrog ib tug retrovirus, bovine leukemia kab mob no (BLV). Nyob rau hauv 2016, 3.125 tus neeg mob ntawm bovine leukemia tau qhia nyob rau hauv Nyiv, uas yog qhov loj tshaj plaws pes tsawg tus ntawm cov mob ntawm cov kab mob bovine kab mob tso cai los ntawm Act rau nyeg tsiaj Kis kab mob Control. Bovine leukemia yog feem ntau pom nyob rau hauv lwm yam neeg Esxias lub teb chaws, South America thiab North America.

Hais txog 35 feem pua ​​ntawm cov nyuj nyob rau hauv Nyiv tau tshaj tawm tus kab mob BLV. Txawm hais tias rampant kab mob tau tshwm sim los ib tug txiav txim economic poob rau chaw yuj nyuj thiab nyuj cov tswv teb, muaj tsis muaj zoo tshuaj tiv thaiv lossis kev kho mob muaj nyob rau cov tswj lub kis thiab kev vam meej ntawm tus kab mob.

Nyob rau hauv ib tug yav dhau los txoj kev tshawb no, zaum los ntawm Hokkaido University, Tohoku University thiab lub Hokkaido tshawb fawb Organization pom hais tias tus lymphocytes hu ua T-cellsare feem suppressed los ntawm ib tug receptor / ligand sis ntawm PD-1 thiab PD-L1 thaum tus kab mob nrog BLV. Lub cev hluav twb ze ze rau kev vam meej ntawm tus kab mob. Tsis tas li ntawd, lawv tsim ib tug anti-PD-L1 antibody uas twb pom zoo nyob rau hauv thaiv cov hlab PD-1 / PD-L1 sis thiab reinvigorating T-cell teb nyob rau hauv lub mob nyuj.

Nyob rau hauv lub tam sim no txoj kev tshawb no, cov kev tshawb fawb pab tsim ib qho anti-PD-1 antibody derived ntawm nas. Lawv ces kuaj nws cov hauj lwm zoo nyob rau hauv ib tug nyuj nyob rau hauv kev tiv thaiv kev vam meej ntawm tus kab mob. Txawm li cas los, tsis muaj teeb meem loj txoj kev txhim kho nyob rau hauv T-cellactivity los yog tus kab mob no count twb pom, thaj vim lub antibody instability nyob rau hauv tus nyuj lub cev thaum administrated.

Cov pab neeg ces engineered lub anti-PD-1 nas antibody tsim ib qho anti PD-1 "nas-bovine" chimeric antibody, uas twb dua muab rau tus kab mob nyuj. Lawv sab tus tshiab khiv tsim antibody blocks lub losis tswvyim dabtsi ntawm PD-1 thiab PD-L1, reinvigorating lub antivirus nruab teb thiab yog li zuj zus lawm tus kab mob no count nyob rau hauv lub mob nyuj. Tsis tas li ntawd, lub antibody yog tsis yooj yim ntiab tawm ntawm lub nyuj lub cev, ua rau nws mus nyob twj ywm zoo li tus nyuj rau ib tug ntev lub sij hawm.

"Tus tshiab antibody yuav leem txoj kev rau cov biomedicines uas zoo kho nyuj uas muaj tus kab bovine leukemia kab mob no. Tej biomedicines kuj yuav tsum tau txo cov kev siv ntawm tshuaj tua kab mob los yog steroids nyob rau hauv lwm yam intractable kis kab mob, "hais tias Associate xibfwb Satoru Konnai ntawm cov kev tshawb fawb pab neeg ntawm Hokkaido University. "Peb yuav npaj mus ua kev cai tsiaj thwmsim xyoo no kom paub tseeb hais tias peb cov tshuaj yog zoo nyob rau hauv kev kho lwm yam kab mob."

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Post lub sij hawm: FEB-27-2018
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